Understanding The Relation Between Asbestos Exposure And Mesothelioma Lung Cancer

An understanding of asbestos is necessary before we try to understand mesothelioma lung cancer. Asbestos, a natural fibrous mineral, used commonly in the construction process and manufacturing industries are detrimental to human health. Continuous inhalation of its fibers enhances the susceptibility to respiratory disorders and can lead to many dangerous diseases. A leading example of such dangerous disease is Mesothelioma lung cancer. Actually, mesothelioma lung cancer is the misnomer because mesothelioma cancers affect the lining of lungs (pleura) and abdomen and not the lungs. Since mesothelioma cancers mostly affect the lining of the lungs, it is generally called mesothelioma lung cancer. The workers who had worked in industries such as shipbuilding, asbestos mining, and asbestos production are vulnerable to mesothelioma cancers.

Mesothelioma and the Role of Carcinogens

What is mesothelioma cancer and how does the lining of the lung become cancerous? Cancer is a tumor that is malignant in nature. The tumor is formed when there are abnormal cell division and cell multiplication in the cancerous cells. Exposure to carcinogens or cancer-causing material like cigarette smoke, asbestos, and silica dust is instrumental in this abnormal cell division and formation of the tumor.

Mesothelioma cancer is directly linked to asbestos exposure. However, those already exposed to asbestos have a greater chance of developing lung cancer if they are exposed to other carcinogens such as cigarette smoke. A study reports that the workers with a history of asbestos exposure and cigarette smoke are more prone to lung cancer than the non-smokers and those with no history of asbestos exposure.

Complications Associated with Mesothelioma Cancer

Normally, the latency stage for asbestos-related diseases in general and mesothelioma cancers of the lining of the lung in particular, 20-50 years, which makes detection of Mesothelioma a complicated issue. This situation is further aggravated particularly where the worker is also addicted to cigarette smoking. By the time, the disease shows its symptoms, a considerable exposure to additional carcinogens linked to cigarette smoking has already taken place. This makes a worker more vulnerable to lung cancer besides the vulnerability to mesothelioma cancers.

Mesothelioma Cancers and Legal Redress

The Government is conscious of the ill effects of asbestos exposure and the seriousness of mesothelioma cancer. The employees working in factories with the significant risk of asbestos exposure are eligible for Mesothelioma compensation if the exposure is the cause of Mesothelioma. There has been a spate of lawsuits for seeking compensation for mesothelioma and lung cancers. In many cases, the courts have awarded heavy sums as compensation against the asbestos manufacturing companies.

Women and Lung Cancer: Researchers Look For Gender Connection

Female Cancer Patients Sought For Large-Scale Clinical Trial

According to a recent survey on health concerns, women fear breast cancer most. Despite the fears expressed in the survey, conducted by the International Communications Research of Media for the Society of Women’s Health Research in 2005, lung cancer is actually the leading cancer killer of women. Lung cancer takes the lives of approximately 68,000 women each year.

While smoking is the biggest risk factor for lung cancer, there is growing evidence that points to gender differences in the risk of developing lung cancer and the implications for treating the disease in men and women.

For example, while the number of men diagnosed with lung cancer has been going down, the number of women has risen 60 percent since 1990. In addition, women who are nonsmokers are 2.5 times more likely to develop lung cancer than men who are nonsmokers.

Scientific evidence points to estrogen as a factor in the difference between how lung cancer acts in men versus women. That biological difference promises to have important implications for lung cancer treatments.

It is believed that the estrogen in women may influence lung tumor growth by causing the synthesis of tumor-promoting proteins. Since women have higher levels of estrogen than men, and younger women have higher levels of estrogen than older women, this may in part be responsible for their higher risk for nonsmall cell lung cancer (NSCLC).

Developing therapies that are favorably influenced by estrogen may provide a gender-targeted therapeutic approach to the treatment of the disease.

Researchers are currently studying a novel approach to targeting lung cancer in women that relies on a chemotherapy agent that exploits the presence of estrogen in women and its effect on the metabolism of proteins in the cancer cell. Cell Therapeutics, Inc. (CTI) developed XYOTAX (paclitaxel poliglumex) initially as a lung cancer drug for all patients-regardless of gender. Retrospective analysis of two Phase III clinical trials found the drug, as compared to standard chemotherapy treatments, had a significant survival advantage in women while having equivalent survival in men.

New clinical trial

Now, Cell Therapeutics is embarking on another clinical study exclusively in women to see if the theory proves true in a larger population of women. The trial, known as PIONEER, is the first approval trial for lung cancer exclusively targeting women and is expected to enroll 600 patients with advanced lung cancer.

What Are The Stages Of Lung Cancer?

Once a diagnosis of lung cancer has been made, the doctor will attempt to determine the stage the lung cancer is at. The staging system is somewhat like a measurement system, with the numbers indicating: whether the cancerous tumors are localized or whether the tumors have spread to other parts of the body; the tumors size; and whether or not the tumors have spread to the lymph nodes. There are four main stages of lung cancer (Stages 1 4) and identification of one of the stages is what helps doctors prescribe an appropriate treatment method.

Different Cancer, Different Stages of Lung Cancer

The staging system is a bit more complicated than simply assigning a number. First of all, the stage numbering system differs slightly depending on whether the lung cancer has been diagnosed as small cell lung cancer or non-small cell lung cancer.

Non-Small Cell Lung Cancer

Non-small cell lung cancer is the more common form and it progresses more slowly than the other type. Non-small lung cancer can be broken down into 4 stages.

Stage 1 means that the tumor is local; it has not spread to the lymph nodes. Adding the letter A or B to the stage 1 classification indicates the size of the tumor (A means it is less than 3 cm across) and whether its larger and growing in a sensitive area (B).

Stage 2 means the tumor has spread into lymph nodes or the chest wall. Again, an A and B designation determines the size and the location of the tumor.

Stage 3 is more complicated and can mean several things. For example, it can indicate that the tumor has spread, but its still only affecting one side of the lung, or that tumors have spread to other nearby body parts such as the chest wall, or that fluid is collecting in the lungs.

Stage 4 is of course the worst stage and means that cancerous tumors have spread into a whole other part of the body like the pelvis or liver.

Small-Cell Cancer

In cases of small-cell cancer, there are two stages of lung cancer Stage 1 and Stage 2. These stages are used to designate whether the cancerous cells are limited in number or whether there exists an extensive amount that have invaded the chest and other parts of the body. When theyre limited in number, patients have a good chance of receiving effective treatment and possibly even resuming a near normal life. An extensive amount however, means treatment options are very limited.

The Staging Challenge

Although the stages of lung cancer seem well-defined, categorizing a persons cancer into one of these stages is often challenging. Each case of cancer involves so many different factors and the combination of factors can be interpreted in many different ways by different doctors. Proper diagnosis and classification takes time and may take several rounds of testing. CT scans, MRIs, blood tests, bone scans and even testing the pleural effusion (if present) may all be needed.